Dr. M. Sajid Hamid Akash

Associate Professor at Government College University Faisalabad

Dr. M. Sajid Hamid Akash

Contact Details

Email Address sajidakash@gcuf.edu.pk
Phone Number 041-9200037
Office Address GC University Faisalabad
Academic Profiles
Google Scholar ORCID Profile Web of Science Scopus Profile
Basic Information
Full Name
Dr. M. Sajid Hamid Akash
Designation
Associate Professor
Department
Pharmaceutical Chemistry
Faculty
Pharmaceutical Sciences
Email Address
sajidakash@gcuf.edu.pk
Brief Statement of research work

My research is a decade-long translational program converting molecular discoveries into public, economic, and environmental benefits, advancing UN Sustainable Development Goals. I investigated molecular pathophysiology of metabolic disorders, effects of environmental toxicants on metabolism, and pragmatic natural-product therapeutics with formulation science. The program links mechanistic discovery, therapeutic innovation, policy engagement, and capacity building to address Pakistan diabetes burden. My portfolio includes seven competitively funded multidisciplinary projects, creating a pipeline from lab discovery to application. A gender-specific biomarker study produced Pakistan first evidence of sex differences in diabetic inflammation, enabling gender-responsive screening. BPA research linked endocrine disruption to T2DM, evaluated plant candidates, and informed regulatory reform (SDG-12). Complementary work validated local bioactives and antidiabetic efficacy of Allium cepa and Zingiber officinale oils, supporting nutraceutical and cottage-industry production (SDG-3, SDG-8). Nicotine studies revealed extra-pancreatic mechanisms, strengthening tobacco-control advocacy. Prediabetes modeling produced predictive screening tools for Pakistan and Saudi Arabia. Heavy-metal susceptibility data informed water-safety and waste-management policies (SDG-6, SDG-11). We developed polymer delivery platforms to improve oral stability and bioavailability and filed a patent for an Alcalase-encapsulated chitosan probiotic matrix. With broad scholarly output and institutional leadership, my work delivers biomarkers, predictive tools, interventions, trained researchers, and industry-ready prototypes with national impact.

Academic Background
SR. DEGREE INSTITUTE FROM TO
1 Ph.D Other University 2010 2015
2 M.Phil Or MS Bahauddin Zakariya University, Multan 2005 2007
3 Master Or Equivalent Bahauddin Zakariya University, Multan 2000 2004
4 Intermedite Or Equivalent BISE Multan 1997 1999
5 Matriculation Or Equivalent BISE Multan 1995 1997
Research Publications
SR. AUTHORS PAPER TITLE JOURNAL PAGE# YEAR VOL. IMP.F VIEW
1 Muhammad Usama Munir, Muhammad Sajid Hamid Akash, Kanwal Rehman, Aisha Rafique, Sehar Madni Untargeted LC-MS/MS Metabolomics Reveals Nrf2-Mediated Antioxidant Activation and Metabolic Reprogramming by IAA-Based Hydrazone Derivatives in Subchronic Cadmium Toxicity Metabolites 155 2026 16 3.7
2 Mahpara Gondal, Muhammad Sajid Hamid Akash, Shagufta Kamal, Kanwal Rehman Metabolomic and biochemical evaluation of linalool and methyl eugenol as natural alternatives to varenicline in nicotine-induced metabolic dysfunction Naunyn-Schmiedebergs Archives of Pharmacology 4043-4065 2026 399 3.1
3 Sehar Madni, Muhammad Sajid Hamid Akash, Shagufta Kamal Synthesis and characterization of indole-3-butyric acid-based hydrazones: from multifunctional enzyme inhibition to therapeutic potential for drug development Naunyn-Schmiedebergs Archives of Pharmacology 2189-2225 2026 399 3.1
4 Sehar Madni, Muhammad Sajid Hamid Akash Integrated metabolomic insights and biochemical profiling of indole-3-butyric acid hydrazones in mitigating heavy metal-induced oxidative and metabolic dysregulation through Nrf2 pathway activation Arabian Journal of Chemistry 5302025 2025 18 5.3
5 Tanveer Raza, Saman Zulfiqar, Amjad Hussain, Muhammad Sajid Hamid Akash, Muhammad Sanwal, Khayala Mammadova, Muhammad Imran, Meher Ali, Muhammad Adnan Ayub, Shoaib Khan, Sajjad Azam Assessing Mercury-Induced Stress on two Commonly Cultivated Mung Bean (Vigna radiata) Varieties: Evaluating its Effect on the Seed Germination and Seedling Growth Phytopharmacology Research Journal 86-100 2025 4 0
6 Amjad Hussain, Sajjad Azam, Rabia Maqsood, Riaz Anwar, Muhammad Sajid Hamid Akash, Hidayat Hussain, Daijie Wang, Muhammad Imran, Katarzyna Kotwica-Mojzych, Shoaib Khan, Shabbir Hussain, Muhammad Adnan Ayub Chemistry, biosynthesis, and theranostics of antioxidant flavonoids and polyphenolics of genus Rhododendron: an overview Naunyn-Schmiedebergs Archives of Pharmacology 1171-1214 2025 398 3.1
7 Syed Muhammad Shoaib, Samina Afzal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain, Ahmed Nadeem, Asif Shahzad, Sabry M. Attia Biochemical Investigation of Association of Arsenic Exposed Polymorphic Variants and Disease Susceptibility Emerging Contaminants 100393 2025 11 6.9
8 Mahpara Gondal , Muhammad Sajid Hamid Akash, Kanwal Rehman Integrated in vivo and in silico ADMET and metabolomic profiling of basil seed bioactives Methyl eugenol and linalool Pakistan Journal of Pharmaceutical Sciences 1254-1271 2025 38 .8
9 Ali Feezan, Samina Afzal, Syed Muhammad Shoaib, Muhammad Sajid Hamid Akash, Kanwal Rehman, Ahmed Nadeem, Sabry M. Attia, Asif Shahzad Impact of lead and nickel contamination on metabolic health: Associations with diabetes mellitus in a Pakistani cohort Emerging Contaminants 100419 2025 11 6.9
10 Hajra Iqbal, Kainat Ilyas, Kanwal Rehman, Muhammad Amtiaz Aslam, Amjad Hussain, Muhammad Ibrahim, Muhammad Sajid Hamid Akash, Mudassar Shahid, Asif Shahzad Metabolomic Analysis of Nicotine-Induced Metabolic Disruptions and Their Amelioration by Resveratrol Journal of Biochemical and Molecular Toxicology e70116 2025 39 3.2
11 Amjad Hussain, Ammara Sohail, Muhammad Sajid Hamid Akash, Sarosh Iqbal, Kanwal Rehman, Muhammad Imran, Shoaib Khan, Muhammad Adnan Ayub, Daijie Wang, Dildar Ahmed, Mohammed Hadi Ali Al-Jumaili, Maria Bashir and Mariam Rasool Marine life as a source of anti-prostate cancer agents: an d overview (2003-2023) Naunyn-Schmiedebergs Archives of Pharmacology 7971-8074 2025 398 3.1
12 Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Amjad Hussain, Mudassar Shahid, Bushra Sadaf Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid-?? Aggregation in Cardiovascular Disease Clinical and Experimental Pharmacology and Physiology e70007 2025 52 2.5
13 Amjad Hussain, Ahmad Bilal, Sajjad Azam, Muhammad Sajid Hamid Akash, Muhammad Imran, Enas Ali, Katarzyna Kotwica-Mojzych, Mariola Glowacka, Mariusz Mojzych, Meher Ali, Muhammad Adnan Ayub, Khayala Mammadova, Afnan Jan, Ajmal Khan Green synthesis of iron and zinc nanoparticles, total phenolic and total flavonoid components, and pharmacological studies of Perovskia atriplicifolia Benth Scientific Reports 39448 2025 15 3.9
14 Rizwan Shaukat, Amjad Hussain, Muhammad Sajid Hamid Akash, Kanwal Rehman, Muhammad Imran, Enas Ali, Meher Ali, Khayala Mammadova, Afnan Jan, Ajmal Khan, Shoaib Khan, Muhammad Adnan Ayub, Munzer Ullah, Ammara Sohail, Hafsa Arshad Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human) The Journal of Gene Medicine e70025 2025 27 3.2
15 Muhammad Sajid Hamid Akash, Francis Victor, Kanwal Rehman, Amjad Hussain, Mudassar Shahid, Asif Shahzad Biochemical investigation of FOXP3 genetic polymorphism and its association with biochemical parameters in pre-eclampsia patients Naunyn-Schmiedebergs Archives of Pharmacology 4583-4592 2025 398 3.1
16 Muhammad Amtiaz Aslam, Hajra Iqbal, Kainat Ilyas, Kanwal Rehman, Amjad Hussain, Muhammad Sajid Hamid Akash, Mudassar Shahid, Shuqing Chen Metabolomic Insights into Smoking-Induced Metabolic Dysfunctions: A Comprehensive Analysis of Lipid and Amino Acid Metabolomes Metabolites 96 2025 96 3.5
17 Muhammad Usama Munir, Muhammad Sajid Hamid Akash, Kanwal Rehman Synthesis, characterization and biological evaluation of indole-3-acetic acid-based hydrazone derivatives Journal of Molecular Structure 141442 2025 1329 4.7
18 Aisha Rafique, Muhammad Sajid Hamid Akash, Kanwal Rehman Exploring the therapeutic potential of benzodioxane carboxylic acid-based hydrazones: Structural, computational, and biological insights Arabian Journal of Chemistry 1292025 2025 18 5.3
19 Amjad Hussain, Faisal Attique, Muhammad Sajid Hamid Akash, Meher Ali, Muhammad Adnan Ayub, Ahmed H. Ragab, Saedah Rwede AL-Mhyawi, Najla F. Gumaah, Khayala Mammadova, Afnan Jan, Muhammad Tahir Saleh Synthesis, Characterization, and Antibacterial Activity of Cephalosporin-Drugs Loaded Ni-Nanoparticles for Drug Carrier Applications BioNanoScience 510 2025 15 3.5
20 Shagufta Kamal, Taleeha Roheen, Kanwal Rehman, Ismat Bibi, Muhammad Sajid Hamid Akash Development of a robust enzyme cascade system: co-immobilization of laccase and versatile peroxidase on polyacrylamide hydrogel for enhanced BPA degradation Biodegradation 34 2025 36 3.4
21 Davis M, Rafique S, Meer S, Afzal Z, Qader A, Asghar A, AKASH MSH Evaluation of non-cytotoxic drugs as potential candidates for breast cancer Journal of Population Therapeutics and Clinical Pharmacology 90???100 2024 31 .3
22 AKASH MSH, Afzaal A, Rehman K, Hussain A, Ibrahim M, Shoaib SM, Shahid M, Sadaf B Identification of Secondary Metabolites of Cyperus rotundus L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes Dose-Response 1-12 2024 22 2.5
23 Kamal S, Babar S, Ali W, Rehman K, Hussain A, AKASH MSH Sirtuin insights: bridging the gap between cellular processes and therapeutic applications Naunyn-Schmiedebergs Archives of Pharmacology 9315-9344 2024 397 3.1
24 Iqbal H, Ilyas K, AKASH MSH, Rehman K, Hussain A, Iqbal J Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes RSC Advances 8837-8870 2024 14 4
25 Feezan A, Afzal S, Shoaib SM, Rehman K, Hussain A, AKASH MSH, Shahid M, Sadaf B Biochemical Impact of Nickel-Induced Metabolic Impairment and the Protective Effects of Resveratrol and Ascorbic Acid Journal of Food Biochemistry 8607956 2024 2024 3.5
26 Hussain A, Azam S, Rehman K, Ali M, AKASH MSH, Zhou X, Rauf A, Alshammari A, Albekairi NA, AL-Ghamdi AH, Quresh AK, Khan S, Khan MU Green synthesis of Fe and Zn-NPs, phytochemistry and pharmacological evaluation of Phlomis cashmeriana Royle ex Benth Heliyon E33327 2024 10 3.7
27 AKASH MSH, Yaqoob S, Rehman K, Hussain A, Chaudhary Z, Nadeem A, Shahzad A, Shah MA, Panichayupakaranant P Biochemical Investigation of Therapeutic Efficacy of Berberine-Enriched Extract in Streptozotocin-Induced Metabolic Impairment ACS Omega 15677???15688 2024 9 4.1
28 Khalid MF, AKASH MSH, Rehman K, Shahzad A, Nadeem A Modulation of Metabolic Pathways and Protection against Cadmium-Induced Disruptions with Taxifolin-Enriched Extract ACS Omega 4057???4072 2024 9 4.1
29 Ilyas K, Rehman K, Iqbal H, Hussain A, AKASH MSH, Shahid M, Sadaf B Metabolomic Analysis and Biochemical Profiling of Cadmium-Induced Metabolic Impairment and Its Amelioration by Resveratrol Bioengineering 1141 2024 11 3.8
30 Kamal S, Shahzad A, Rehman K, Tariq K, AKASH MSH, Imran M, Assiri MA Therapeutic Intervention of Serine Protease Inhibitors against Hepatitis C Virus Current Medicinal Chemistry 2052-2072 2024 31 4.6
31 Kainat Ilyas, Hajra Iqbal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain Heavy metal exposure and metabolomics analysis: an emerging frontier in environmental health Environmental Science and Pollution Research 37963???37987 2024 31 5.4
32 Irshad K, AKASH MSH, Rehman K, Nadeem A, Shahzad A Biosynthesis and Multifaceted Characterization of Breynia nivosa-Derived Silver Nanoparticles: An Eco-Friendly Approach for Biomedical Applications ACS Omega 15383???15400 2024 9 4.1
33 AKASH MSH, Sumbal R, Rehman K, Imran M, Assiri MA Toxicological evaluation of bisphenol analogues: preventive measures and therapeutic interventions RSC Advances 21613-21628 2023 13 4
34 AKASH MSH, Noureen S, Rehman K, Nadeem A and Khan MA Investigating the biochemical association of gestational diabetes mellitus with dyslipidemia and hemoglobin Frontiers in Medicine 1242939 2023 10 4.5
35 AKASH MSH, Fatima M, Rehman K, Rehman Q, Chauhdary Z, Nadeem A, Mir TM Resveratrol Mitigates Bisphenol A-Induced Metabolic Disruptions: Insights from Experimental Studies Molecules 5865 2023 28 4.6
36 Shoaib SM, Afzal S, Feezan A, AKASH MSH, Nadeem A, Mir TM Metabolomics Analysis and Biochemical Profiling of Arsenic-Induced Metabolic Impairment and Disease Susceptibility Biomolecules 1424 2023 13 5.5
37 Jabeen K, Rehman K. AKASH MSH, Nadeem A, Mir TM Neuroprotective and Cardiometabolic Role of Vitamin E: Alleviating Neuroinflammation and Metabolic Disturbance Induced by AlCl3 in Rat Models Biomedicines 2453 2023 11 4.7
38 Victor F, Rehman K, AKASH MSH, Sumbal R, Imran M, Assiri MA Technological Advancement in ??-3 Fatty Acids: Their Therapeutic Functions and Novel Delivery Strategies Current Pharmaceutical Design 893 ??? 903 2023 29 3.3
39 Shahid M, Rehman K, AKASH MSH, Suhail S, Rasheed S, Imran M, Assiri MA Biochemical association between the prevalence of genetic polymorphism and myocardial infarction BIOCELL 473-484 2023 47 1.2
40 Mallhi TH, Shahid M, Rehman K, Khan YH, Alanazi AS, Alotaibi NH, AKASH MSH, Butt MH. Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor Metabolites 251 2023 13 5.5
41 Rehman K, Afzaal A, AKASH MSH, Imran M, Assiri MA Interleukin-1 receptor antagonist: From synthesis to therapeutic applications BIOCELL 809-823 2023 47 1.2
42 Tariq M, Hussain N, Rehman K, AKASH MSH, Al Haddad AHI, Said ASA, Fatease AA, Alamri A, Safhi AY, Sabei FY, Al Awadh AA, Hussain M Macrophages M2 polarization is involved in lapatinib-mediated chemopreventive effects in the lung cancer Biomedicine & Pharmacotherapy 114527 2023 161 7.4
43 AKASH MSH, Akbar M, Rehman K, Shah MA, Panichayupakaranant P, Imran M, Assiri MA Biochemical profiling of berberine-enriched extract in aluminum chloride induced oxidative damage and neuroinflammation Environmental Science and Pollution Research 85263???85275 2023 30 5.8
44 Alanazi AS, Rasheed S, Rehman K, Mallhi TH, AKASH MSH, Alotaibi NH, Alzarea AI, NT, Khan YH Biochemical association of regulatory variant of KLF14 genotype in the pathogenesis of cardiodiabetic patients Frontiers in Endocrinology 1176166 2023 14 6
45 AKASH MSH, Shahid M, Suhail S, Rehman K, Nadeem A, Mir TM Tetra-ARMS PCR analysis of angiotensinogen AGT T174M (rs4762) genetic polymorphism in diabetic patients: a comprehensive study Frontiers in Endocrinology 1240291 2023 14 6
46 Assiri MA, Ali A, Ibrahim M, Khan MU, Ahmed K, AKASH MSH, Abbas MA, Javed A, Suleman M, Khalid M, Hussain I Potential anticancer and antioxidant lauric acid-based hydrazone synthesis and computational study toward the electronic properties RSC Advances 21793???21807 2023 13 4
47 AKASH MSH, Yaqoob A, Rehman K, Imran M, Assiri MA, Al-Rashed F, Al-Mulla F, Ahmad R, Sindhu S A Promising Tool for Deciphering Metabolic Impairment in Heavy Metal Toxicities Frontiers in Molecular Biosciences 1218497 2023 10 6.13
48 AKASH MSH, Sumbal R, Rehman K, Ibrahim M, Imran M, Assiri MA Biochemical Activation and Regulatory Functions of Trans-Regulatory KLF14 and Its Association with Genetic Polymorphisms Metabolites 199 2023 13 5.5
49 Alvi M, Yaqoob A, Rehman K, Shoaib SM, AKASH MSH PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives AAPS Open 12 2022 8 4.1
50 Alanazi AS, Victor F, Rehman K, Khan YH, Yunusa I, Alzarea AI, AKASH MSH, Malhi TH Pre-Existing Diabetes Mellitus, Hypertension and KidneyDisease as Risk Factors of Pre-Eclampsia: A Disease of Theories and Its Association with Genetic Polymorphism International Journal of Environmental Research and Public Health 16690 2022 19 4.6
51 Jabeen K, Rehman K, AKASH MSH Genetic mutations of APOE??4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease Journal of Biochemical and Molecular Toxicology e22953 2022 36 3.6
52 Asif HMA, Kamal S, Rehman A, Rasool S, AKASH MSH Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues ACS Omega 32360-32368 2022 7 4.1
53 Noureen S, Rehman K, AKASH MSH Natural Immunity Boosters as Therapeutic Interventions in the Era of the COVID-19 Pandemic Endocrine, Metabolic & Immune Disorders - Drug Targets 842???851 2022 22 3
54 Afzaal A, Rehman K, Kamal S, AKASH MSH Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions Journal of Biochemical and Molecular Toxicology e23047 2022 36 3.6
55 AKASH MSH, Qader A, Rehman K Insulin resistance susceptibility is associated with BPA exposure Metabolism 154973 2022 128 13.9
56 Rehman K, Niaz S, Tahir A, Jabeen K AKASH MSH FTO, PPAR-?? and ABCC8 gene variation and hypertension as determinants of cardiometabolic risk in CVD patients Metabolism 154972 2022 128 13.9
57 Sabir S, Saleem U, AKASH MSH, Qasim M, Chauhdary Z Thymoquinone Induces Nrf2 Mediated Adaptive Homeostasis: Implication for Mercuric Chloride-Induced Nephrotoxicity ACS Omega 7370???7379 2022 7 4.1
58 Batool JA, Rehman K, Qader A, AKASH MSH Biomedical Applications of Carbohydrate-based Polyurethane: From Biosynthesis to Degradation Current Pharmaceutical Design 1669-1687 2022 28 3.3
59 Saleem Z, Rehman K, AKASH MSH Role of Drug Delivery System in Improving the Bioavailability of Resveratrol Current Pharmaceutical Design 1632???1642 2022 28 3.3
60 Khalid MF, Rehman K, Irshad K, Chohan TA, AKASH MSH Biochemical Investigation of Inhibitory Activities of Plant-Derived Bioactive Compounds Against Carbohydrate and Glucagon-Like Peptide-1 Metabolizing Enzymes Dose-Response 1-16 2022 20 2.6
61 Riaz S, Hussain I, Ibrahim M, Ishtiaq M, Ali Q, Ali MM, AKASH MSH Extraction and Optimization of Active Metabolites From Cluster Bean: An In Vitro Biological and Phytochemical Investigation Dose-Response 1-12 2022 20 2.6
62 Yaqoob A, Rehman K, AKASH MSH, Alvi M, Shoaib SM Biochemical profiling of metabolomics in heavy metal-intoxicated impaired metabolism and its amelioration using plant-based bioactive compound Frontiers in Molecular Biosciences 1029729 2022 9 6.1
63 Rasheed S, Rehman K, Shahid M, Suhail S, AKASH MSH Therapeutic potentials of genistein: New insights and perspectives Journal of Food Biochemistry e14228 2022 46 3.6
64 AKASH MSH, Sharif H, Rehman K, Rasheed S, Kamal S Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways Pakistan Journal of Zoology 2835-2844 2022 54 .8
65 Rehman K, Qader A, Haq MEU, AKASH MSH Long-term exposure of Bisphenol A impairs metabolism and develop insulin resistance Metabolism 154974 2022 128 13.9
66 Javed A, Muzammal A, AKASH MSH, Rehman K Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion Dose-Response 1-12 2022 20 2.6
67 Shabbir A, Rehman K, AKASH MSH, Akbar M, Chaudhary Z, Panichayupakaranant P, Shah MA Differential neuroprotective effect of curcuminoid formulations in aluminum chloride???induced Alzheimer???s disease Environmental Science and Pollution Research 67981-67996 2022 29 5.1
68 Alvi M, Rehman K, AKASH MSH, Yaqoob A, Shoaib SM Determination of Metabolomics Profiling in BPA-Induced Impaired Metabolism Pharmaceutics 2496 2022 14 6.5
69 Shahid M, Rehman K, AKASH MSH, Suhail S, Kamal S, Imran M, Assiri MA Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases Metabolites 1291 2022 12 5.5
70 Qader A, Rehman K, AKASH MSH Biochemical profiling of lead-intoxicated impaired lipid metabolism and its amelioration using plant-based bioactive compound Environmental Science and Pollution Research 60414-60425 2022 29 5.1
71 Shabbir A, Rehman K, Akbar M, AKASH MSH Neuroprotective Potential of Curcuminoids in Modulating Alzheimer???s Disease via Multiple Signaling Pathways Current Medicinal Chemistry 5560-5581 2022 29 4.7
72 Ali MZ, Mehmood MH, Saleem M, AKASH MSH, Malik A Pharmacological evaluation of Euphorbia hirta, Fagonia indica and Capparis decidua in hypertension through in-vivo and in vitro-assays Heliyon e08094 2021 7 2.8
73 Akbar M, Shabbir A, Rehman K, AKASH MSH Neuroprotective potential of berberine in modulating Alzheimer???s disease via multiple signaling pathways Journal of Food Biochemistry e13936 2021 45 2.7
74 Irshad K, Rehman K, AKASH MSH Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication Dose-Response 1-13 2021 19 2.6
75 Rasheed S, Rehman K, AKASH MSH An insight into the risk factors of brain tumors and their therapeutic interventions Biomedicine & Pharmacotherapy 112119 2021 143 7.4
76 Chaudhary Z, Rehman K, AKASH MSH The composite alliance of FTO locus with obesity?related genetic variants Clinical and Experimental Pharmacology and Physiology 954?965 2021 48 2.5
77 Rehman K, Haider K, AKASH MSH Cigarette smoking and nicotine exposure contributes for aberrant insulin signaling and cardiometabolic disorders European Journal of Pharmacology 174410 2021 909 4.4
78 Qureshi QH, Ashraf T, Rehman K, Khosa MK, AKASH MSH Therapeutic interventions of remdesivir in diabetic and non-diabetic COVID-19 patients: A prospective observational study conducted on Pakistani population Journal of Medical Virology 6732?6736 2021 93 2.32
79 Shahid A, Ali MA, Muzammil S, Aslam B, Shahid M, Saqalein M, AKASH MSH, Almatroudi A, Allemailem KS, Khurshid M Antibiotic residues in food chains; impact on the environment and human health: A Review APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH 3959-3977 2021 19 .71
80 Qader A, Rehman K, AKASH MSH Genetic susceptibility of ?-ALAD associated with lead (Pb) intoxication: Sources of exposure, preventive measures and treatment interventions Environmental Science and Pollution Research 44818?44832 2021 28 5.19
81 Rehman K, AKASH MSH Early Detection of Insulin Resistance and Assorted Metabolic Dysfunctions through MicroRNA-141 Metabolism 154518 2021 116 13.934
82 Qader A, Rehman K, AKASH MSH Genetic susceptibility of ??-ALAD associated with lead (Pb) intoxication: Sources of exposure, preventive measures and treatment interventions Environmental Science and Pollution Research 44818-44832 2021 28 5.19
83 AKASH MSH, Rehman K Exposure of Endocrine Disrupting Chemical is a Risk Factor for the Pathogenesis and Development of Metabolic Disorders Metabolism 154498 2021 116 13.934
84 AKASH MSH, Haq ME, Qader A, Rehman K Biochemical investigation of human exposure to aflatoxin M1 and its association with risk factors of diabetes mellitus Environmental Science and Pollution Research 44818???44832 2021 28 5.19
85 AKASH MSH, Rehman K, Irshad K Prevalence of contamination of aflatoxin M1 in milk: a retrospective analysis of studies conducted in Pakistan Environmental Monitoring and Assessment 456 2021 193 3.1
86 Chaudhary Z, Rehman K, AKASH MSH The composite alliance of FTO locus with obesity???related genetic variants Clinical and Experimental Pharmacology and Physiology 954???965 2021 48 2.5
87 Hussain I, Rehman K, Ashraf MA, Rasheed R, Gul J, AKASH MSH, Bashir R Effect of pharmaceutical effluents on growth, oxidative defense, secondary metabolism and ion homeostasis in carrot Dose?Response 1-11 2021 19 2.6
88 Rehman K, Irshad K, Kamal S, Imran I, AKASH MSH Exposure of environmental contaminants and development of neurological disorders Critical Reviews in Eukaryotic Gene Expression 35-53 2021 31 2.2
89 Rehman K, Rahid U, Jabeen K, AKASH MSH Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation Asian Pacific Journal of Tropical Biomedicine 148-154 2021 11 1.9
90 Haq ME, AKASH MSH, Rehman K, Mahmood MH Essential oils downregulate pro-inflammatory cytokines and nitric oxide-mediated oxidative stress in alloxan-induced diabetogenic rats Endocrine, Metabolic & Immune Disorders - Drug Targets 756-767 2021 21 3.03
91 AKASH MSH, Rehman K, Jabeen K, Fiayyaz F, Sabir S, Haq ME Assessment of knowledge, attitude and practice of Pakistani population about the risk factors, causes, complications and management of diabetes mellitus Journal of the Pakistan Medical Association 286-296 2021 71 .7
92 Irshad K, AKASH MSH, Rehman K, Sharif H Therapeutic Interventions of Novel SGLT2 Inhibitors Against Metabolic Disorders: Transforming the Association into Perspectives Endocrine, Metabolic & Immune Disorders - Drug Targets 2169?2180 2021 21 3
93 Rehman K, Tahir A, Niaz S, Shabbir S, Jabeen K, Faheem A, AKASH MSH Frequency of PPAR-??, FTO and ABCC8 genetic variation in Pakistani cardiovascular smokers Environmental Science and Pollution Research 42611-42620 2020 27 5.19
94 Faheem A, Rehman K, Jabeen K, AKASH MSH Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance Environmental Toxicology and Pharmacology 103506 2020 80 4.8
95 Ahmed B, Basheer R, Irfan M, AKASH MSH, Muhammad SA, Qadir MI Mini-Review: molecular elucidations of hutchinson-gilford progeria syndrome: A hope for managing horrors of premature aging in children Pakistan Journal of Pharmaceutical Sciences 1179-1182 2020 33 .8
96 AKASH MSH, Sabir S, Rehman K Bisphenol A-induced metabolic disorders: From exposure to mechanism of action Environmental Toxicology and Pharmacology 103373 2020 77 4.8
97 Saba S, AKASH MSH, Rehman K, Saleem U, Fiayyaz F, Ahmad T Assessment of heavy metals by ICP-OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes Clinical and Experimental Pharmacology and Physiology 1682-1691 2020 47 2.5
98 Chohan TA, Sarfraz M, Rehman K, Tariq M, Ghori MU, Khan KM, Afzal I, AKASH MSH, Malik A, Chohan TA Phytochemical profiling, antioxidant and antiproliferation potential of Euphorbia milii var.: Experimental analysis and in-silico validation Saudi Journal of Biological Sciences 3025-3034 2020 27 4.2
99 Noor S, Rasul A, Iqbal MS, Ahmed B, AKASH MSH, Qadir MI Inhibition of hepatitis B virus with the help of CRISPR/Cas9 technology Critical Reviews??? in Eukaryotic Gene Expression 273???278 2020 30 2.2
100 Qadir MI, Rasul A, AKASH MSH, Irfan M, Ibrahim MR, Hussain SB Importance of vitamin D in cancer management Pakistan Journal of Pharmaceutical Sciences 1711-1718 2020 3 .8
101 Rehman K, Jabeen K, Awan FR, Hussain M, Saddique MA, AKASH MSH Biochemical investigation of rs1801282 variations in PPAR-?? gene and its correlation with risk factors of diabetes mellitus in coronary artery disease Clinical and Experimental Pharmacology and Physiology 1517???1529 2020 47 2.5
102 Khurshid M, AKASH MSH Probiotic preparations for infantile gastroenteritis; the clinical and economic perspective Future Microbiology 567???569 2020 15 3.1
103 Manan M, Saleem U, AKASH MSH, Qasim M, Hayat M, Raza Z, Ahmad B Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies ACS Omega 19478-19496 2020 5 4.1
104 Rehman K, Khan II, AKASH MSH, Jabeen K, Haider K Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia Journal of Food Biochemistry 13422 2020 44 2.7
105 Hina S, AKASH MSH, Rehman K, Irshad K, Imram I. Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant-based bioactive compounds Journal of Food Biochemistry 13449 2020 44 2.7
106 Haq ME, AKASH MSH, Sabir S, Mahmood MH, Rehman K Human exposure to bisphenol A through dietary sources and development of diabetes mellitus: a cross-sectional study in Pakistani population Environmental Science and Pollution Research 26262-26275 2020 27 5.1
107 Rehman K, Haider K, Jabeen K, AKASH MSH Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes Reviews in Endocrine and Metabolic Disorders 631-43 2020 21 9.3
108 Kamal S, Junaid M, Ejaz A, Bibi I, AKASH MSH, Rehman K The secrets of telomerase: Retrospective analysis and future prospects Life Sciences 118115 2020 257 6.7
109 Rehman K, Munawar SM, AKASH MSH, Buabeid MA, Chohan TA, Tariq M, Jabeen K, El- Arafa EA Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation PLOS ONE 0227637 2020 15 3.2
110 Munir S, Shah AA, Shahid M, Ahmed MS, Shahid A, Rajoka MSR, AKASH MSH, Akram M, Khurshid M Anti-angiogenesis Potential of Phytochemicals for the Therapeutic Management of Tumors Current Pharmaceutical Design 265-278 2020 26 3.1
111 AKASH MSH, Rehman K, Fiayyaz F, Sabir S, Khurshid M Diabetes-associated infections: development of antimicrobial resistance and possible treatment strategies Archives of Microbiology 953???965 2020 202 2.5
112 Haq ME, AKASH MSH, Rehman K, Mahmood MH Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways Environmental Toxicology and Pharmacology 103387 2020 78 4.8
113 Munir S, Shahid A, Aslam B, Ashfaq UA, Akash MSH, Ali MA, Almatroudi A, Allemailem KS, Rajoka MS, Khurshid M The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders Evidence-Based Complementary and Alternative Medicine 8836983 2020 2020 2.6
Professional Journey
SR. POST HELD INSTITUTE / ORGANIZATION DURATION EXPERIENCE (Y/M/D)
1 Associate Professor Department of Pharmaceutical Chemistry, Government College University Faisalabad 2018 - 0/0/0
2 Assistant Professor Government College University Faisalabad, Pakistan 2015 - 2018 3/7/5
3 Lecturer Government College University Faisalabad, Pakistan 2009 - 2015 5/5/16
4 Lecturer The University of Lahore, Lahore, Pakistan 2008 - 2009 1/2/25
5 Production Pharmacist MediPak Pharma. PVT. (Ltd.), Lahore, Pakistan 2005 - 2006 1/5/5
6 Production Pharmacist Production Dept., Askari Pharmaceuticals, Distt. Kasur, Pakistan 2004 - 2005 0/5/5
International Exposure
SR. COUNTRY FUNDING AGENCY DURATION (Y/M/D) PURPOSE
1 CHINA China Scholarship Councul 4/6/0 For PhD study
Professional qualifications & traninings
SR. INSTITUTE CERTIFICATE YEAR MAJOR SUBJECT
1 Journal of Clinical Medicine, MDPI CERTIFICATE OF COMPLETION 2025 - 2025 Glomerular Diseases - Pathology and Treatment
2 Center for Learning and Teaching, FCCU, Lahore, Pakistan CERTIFICATE OF COMPLETION 2025 - 2025 Literature Review - Research Methodology
3 Wiley Research Training, John Wiley and Sons CERTIFICATE OF COMPLETION 2025 - 2025 Role of AI in Open Access Publishing
4 OIC-COMSTECH and Ningbo University, China CERTIFICATE OF COMPLETION 2025 - 2025 Applied Biomedical AI
5 Researcher Academy, ELSEVIER CERTIFICATE OF PARTICIPATION 2025 - 2025 Realistic Approaches to Publishing
6 Researcher Academy, ELSEVIER CERTIFICATE OF COMPLETION 2025 - 2025 Shorten Your Path to Publication
7 Reviewer Credits CERTIFICATE OF PARTICIPATION 2024 - 2024 Potential of AI in Peer Review
8 NPO, Ministry of Industries and Production, Pakistan CERTIFICATE OF COMPLETION 2024 - 2024 Awareness and Implementation of ISO 21500:2021 Project Management
9 Quality Enhancement Cell (QEC), GCUF CERTIFICATE OF PARTICIPATION 2024 - 2024 Review of Institutional Performance and Enhancement (RIPE)
10 NPO, Ministry of Industries and Production, Pakistan CERTIFICATE IN PORTFOLIO MANAGEMENT PROFESSIONAL 2024 - 2024 Portfolio Management
11 NAHE-HEC and British Council Pakistan MASTER TRAINER CERTIFICATE 2023 - 2023 PhD Supervisors Capacity Building (Pak-UK Gateway)
12 Wolters Kluwer with HEC CERTIFICATE OF COMPLETION 2023 - 2023 OVID Database Training
13 Researcher Academy, ELSEVIER CERTIFICATE OF COMPLETION 2023 - 2023 Publishing in High-Quality Journals using ScienceDirect
14 Department of Education, GCUF CERTIFICATE OF PARTICIPATION 2023 - 2023 Role of University Teachers in Academic Planning and Teaching
15 HEC and British Council (Pak-UK Education Gateway) CERTIFICATE OF COMPLETION 2023 - 2023 Reviewers Capacity Building Program
16 COMSTECH, Islamabad and York Biomedical Research Institute, UK CERTIFICATE OF PARTICIPATION 2021 - 2021 CRISPR-Cas9 Genome Editing and Drug Target Validation
17 ProQuest and HEC CERTIFICATE OF PARTICIPATION 2020 - 2020 Remote Access to HEC Digital Library and ProQuest Databases
18 Department of Chemistry, GCUF and Pakistan Society of Nuclear Medicine CERTIFICATE OF PARTICIPATION 2017 - 2017 Drug Development and Radiolabeled Compounds
19 NIBGE, Faisalabad, Pakistan CERTIFICATE OF COMPLETION 2016 - 2016 Modern Techniques in Biotechnology
20 Government College University, Faisalabad (GCUF) CERTIFICATE OF COMPLETION 2016 - 2016 Government???Academia???Industry Linkage
21 HEC Regional Center, Lahore CERTIFICATE OF PARTICIPATION 2016 - 2016 Implementation of Plagiarism Policy and Turnitin
22 Pakistan Institute of Entrepreneurship & Falcon Consulting CERTIFICATE OF PARTICIPATION 2016 - 2016 Improving Industry-Academia Linkage
23 ORIC, GCUF and Rays Technologies, Lahore CERTIFICATE OF COMPLETION 2016 - 2016 Infrared Spectroscopy: Principles and Applications
24 Intellectual Property Rights CERTIFICATE OF COMPLETION 2016 - 2016 Patent Filing vs Commercialization
25 Government College University, Faisalabad (GCUF) CERTIFICATE OF COMPLETION 2016 - 2016 Government???Academia???Industry Linkage
26 Punjab Pharmacy Council, Lahore CERTIFICATE OF COMPLETION 2015 - 2015 Pre-Renewal Training for Pharmacy Practice
27 Dept. of Chemistry and Central Hi-Tech Lab, UAF CERTIFICATE OF COMPLETION 2015 - 2015 Advanced Chemical Techniques
28 NAYS and Dept. of Biochemistry, UAF CERTIFICATE OF COMPLETION 2015 - 2015 Biosafety Training for Young Scientists
29 GCUF and PASTIC CERTIFICATE OF COMPLETION 2015 - 2015 Intellectual Property Rights
30 UVAS, Lahore, Pakistan CERTIFICATE OF COMPLETION 2009 - 2009 Operation and Application of HPLC
31 UVAS, Lahore, Pakistan CERTIFICATE OF COMPLETION 2009 - 2009 Laboratory Instrumentation and Quality Aspects
32 Department of Computer Science, BZU, Pakistan CERTIFICATE OF COMPLETION 2001 - 2001 Computer Literacy Program
33 Multan Battalion, National Cadet Corps and Women Guards CERTIFICATE OF COMPLETION 1998 - 1998 National Cadet Corps Training
Research Projects
SR. PROJECT TITLE PROJECT DETAIL ABSTRACT FUNDING AGENCY
1
Beyond pancreas: Investigation of novel targets and treatment for nicotine-induced diabetes mellitus
6429/PUNJAB/NRPU/RND/HEC/2016
This project found that chronic nicotine exposure disrupts glucose homeostasis by inducing insulin resistance, ??-cell dysfunction, oxidative stress, inflammation, and mitochondrial impairment. Untargeted metabolomics revealed consistent amino-acid and lipid pathway perturbations linked to these defects. Preclinical interventions with resveratrol normalized key metabolic and metabolomic markers, reduced oxidative/inflammatory burden, protected organs, and improved glycaemia and insulin sensitivity. Outcomes identify non-pancreatic targets (redox, inflammatory and mitochondrial pathways), support nutraceutical mitigation strategies, and justify translational evaluation alongside policies to reduce nicotine exposure.
HEC Pakistan
2
Heavy Metal Induced Disease Susceptibility
SAF/024/010
This project investigated mechanistic links between heavy-metal exposure and disease susceptibility. Integrated biochemical, toxicological, and molecular analyses demonstrated that arsenic and related metals induce oxidative stress, mitochondrial dysfunction, and pro-inflammatory signaling, thereby impairing glucose and lipid metabolism and increasing cardiometabolic risk. Experimental models showed disruption of insulin signaling pathways, altered antioxidant defenses, and tissue-specific metabolic derangements. Biomarker profiling identified redox and inflammatory indices as early indicators of toxicity. Importantly, ed plant-derived bioactives attenuated metal-induced metabolic and oxidative abnormalities. These findings provide mechanistic evidence for heavy-metal???associated disease vulnerability and support preventive strategies, exposure control policies, and development of protective nutraceutical interventions.
Saffron Pharmaceuticals (Pvt.) Limited, Faisalabad, Pakistan
3
Evaluation of risk factors associated with the development of prediabetes
DSR2022-RG-0144
The DSR2022-RG-0144???supported studies elucidated metabolic and genetic risk factors linking prediabetes with cardiometabolic complications. Clinical analyses confirmed that diabetes and hypertension significantly increase the risk of adverse outcomes, including pre-eclampsia and cardiovascular events. Molecular investigations demonstrated that the MTHFR C677T polymorphism is associated with altered homocysteine metabolism and heightened myocardial infarction susceptibility in diabetic patients. Additionally, regulatory variants of KLF14 were significantly associated with dyslipidemia, insulin resistance, and cardiodiabetic phenotypes. Collectively, these findings integrate clinical and genetic evidence to refine risk stratification, enabling early identification of high-risk individuals and supporting precision-based preventive strategies.
Ministry of Education, Kingdom of Saudi Arabia
4
Investigations of therapeutic potentials of Allium cepa and Zingiber officinale essential oils on various pathways involved in diabetes mellitus
GCUF/REG/17/3682
This project showed that essential oils of Allium cepa and Zingiber officinale provide complementary antidiabetic actions. In vitro and animal studies demonstrated ??-amylase and ??-glucosidase inhibition, antioxidant and anti-inflammatory effects, enhancement of insulin signaling and GLUT4 translocation, and improved mitochondrial function, cumulatively reducing hyperglycaemia and insulin resistance. Phytochemical profiling identified sulfur compounds, flavonoids, and gingerols as active constituents. Preclinical intervention reduced oxidative markers and normalized key metabolic biomarkers. Outcomes support development of onion and ginger essential-oil???based nutraceuticals and justify progression to clinical evaluation and formulation optimization for diabetes adjunct therapy.
GCUF
5
Biochemical investigation of association of endocrine disrupting chemicals with insulin-stimulating and carbohydrate metabolizing hormones in diabetes mellitus and their treatment strategies using plant-based bioactive compounds
8365/PUNJAB/NRPU/RND/HEC/2017
This project demonstrated that EDCs disrupt insulin-stimulating and carbohydrate-metabolizing hormones, contributing to impaired glucose homeostasis. Combined human, animal, and biochemical studies linked arsenic and BPA exposure to altered insulin, glucagon, and incretin signaling, elevated insulin resistance, and modulation of ??-amylase/??-glucosidase activity. Metabolomics and mechanistic assays implicate oxidative stress, inflammation, and mitochondrial dysfunction as mediators. In vitro and in vivo screening identified plant-derived bioactives (resveratrol, taxifolin) that inhibit carbohydrate-metabolizing enzymes, restore hormonal and metabolic markers, reduce oxidative/inflammatory load, and improve glycemic outcomes - supporting nutraceutical strategies and exposure-reduction policies. Findings warrant clinical translation and policy action nationwide in Pakistan.
HEC Pakistan
6
Bisphenol A - associated type 2 diabetes mellitus: Pathogenesis and prospects for treatment
5661/PUNJAB/NRPU/RND/HEC/2016
This project integrated epidemiology, controlled animal studies, metabolomics, and interventional experiments to elucidate how chronic BPA exposure promotes T2DM and to evaluate natural-product mitigants. Environmentally relevant BPA doses disrupted glucose homeostasis by inducing insulin resistance, impairing ??-cell function, and altering adipokine and lipid metabolism. Metabolomics revealed perturbations in amino acid, fatty acid, and energy pathways consistent with mitochondrial dysfunction and oxidative stress. Mechanistic analyses implicated inflammatory signaling and redox imbalance. Resveratrol and related phytochemicals reversed metabolic abnormalities and improved insulin sensitivity, supporting translational mitigation strategies and evidence-informed policy to reduce BPA exposure.
HEC Pakistan
7
Gender-specific association between serum inflammatory biomarkers and insulin resistance in diabetic patients
21-1061/SRGP/RND/HEC/2016
This research funded by HEC examined serum IL-6, TNF-?? and CRP in Pakistani type 2 diabetic patients to determine sex-specific links with insulin resistance. In a cross-sectional cohort, higher IL-6, TNF-?? and CRP correlated with HOMA-IR, with associations markedly stronger in women and partially mediated by greater BMI and central adiposity. Multivariate analyses and mechanistic interpretation indicate sexual dimorphism in inflammatory contributions to insulin resistance. These findings support incorporating inflammatory biomarkers into diabetes risk stratification and endorse sex-tailored prevention and therapeutic strategies targeting inflammation and adiposity to reduce diabetes progression nationwide in Pakistani clinical settings.
Higher Education Commission of Pakistan